{"id":1190,"date":"2026-07-14T13:46:59","date_gmt":"2026-07-14T13:46:59","guid":{"rendered":"https:\/\/d2top.ulpgc.es\/?page_id=1190"},"modified":"2026-07-16T15:25:46","modified_gmt":"2026-07-16T15:25:46","slug":"proyecto","status":"publish","type":"page","link":"https:\/\/d2top.ulpgc.es\/index.php\/proyecto\/","title":{"rendered":"Proyecto"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk-block stk-7fa31a3\" data-block-id=\"7fa31a3\"><style>.stk-7fa31a3 {padding-top:var(--stk--preset--spacing--none, 0px) !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-7fa31a3-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-56f9e8b\" data-v=\"4\" data-block-id=\"56f9e8b\"><style>.stk-56f9e8b-inner-blocks{align-items:center !important;}.stk-56f9e8b-container{background-color:var(--theme-palette-color-1, #0054a6) !important;}.stk-56f9e8b-container:before{background-color:var(--theme-palette-color-1, #0054a6) !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-56f9e8b-container stk-hover-parent\"><div class=\"stk--column-flex stk-block-content stk-inner-blocks stk-56f9e8b-inner-blocks\">\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-10f164d\" data-block-id=\"10f164d\"><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-6a6b67e\" id=\"proyecto-d-span-style-color-fcb-900-class-stk-highlight-2-span-top\" data-block-id=\"6a6b67e\"><style>.stk-6a6b67e .stk-block-heading__text{font-size:48px !important;color:var(--theme-palette-color-8, #ffffff) !important;}@media screen and (max-width:999px){.stk-6a6b67e .stk-block-heading__text{font-size:48px !important;}}<\/style><h1 class=\"stk-block-heading__text has-text-color\">Proyecto D<span style=\"color: #fcb900;\" class=\"stk-highlight\">2<\/span> Top<\/h1><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-ce242c5\" data-block-id=\"ce242c5\"><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk-block stk-daab7cf\" data-block-id=\"daab7cf\"><style>.stk-daab7cf {margin-bottom:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-daab7cf-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-b15c2b7\" data-v=\"4\" data-block-id=\"b15c2b7\"><style>.stk-b15c2b7-inner-blocks{justify-content:center !important;}.stk-b15c2b7-container{padding-top:var(--stk--preset--spacing--20, 0.44rem) !important;padding-right:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--20, 0.44rem) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-b15c2b7-container stk-hover-parent\"><div class=\"stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-b15c2b7-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-d985aaf\" data-block-id=\"d985aaf\"><style>.stk-d985aaf .stk-inner-blocks{column-gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-button stk-block-button is-style-plain stk-block stk-2158cbc\" data-block-id=\"2158cbc\"><style>.stk-2158cbc .stk-button{background:transparent !important;}.stk-2158cbc .stk-button:hover:after{background:transparent !important;opacity:1 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-2158cbc .stk-button:after{background:transparent !important;opacity:1 !important;}.stk-2158cbc .stk-button__inner-text{color:#787e83 !important;}.stk-2158cbc .stk-button:hover .stk-button__inner-text{color:var(--theme-palette-color-1, #0054a6) !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"#1-justificacion-cientifica-por-que-este-proyecto\"><span class=\"has-text-color stk-button__inner-text\"><strong>Justificaci\u00f3n<\/strong><\/span><\/a><\/div>\n\n\n\n<div class=\"wp-block-stackable-button stk-block-button is-style-plain stk-block stk-6dd50df\" data-block-id=\"6dd50df\"><style>.stk-6dd50df .stk-button{background:transparent !important;}.stk-6dd50df .stk-button:hover:after{background:transparent !important;opacity:1 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-6dd50df .stk-button:after{background:transparent !important;opacity:1 !important;}.stk-6dd50df .stk-button__inner-text{color:#787e83 !important;}.stk-6dd50df .stk-button:hover .stk-button__inner-text{color:var(--theme-palette-color-1, #0054a6) !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"#2-hipotesis-de-partida-y-objetivos\"><span class=\"has-text-color stk-button__inner-text\"><strong>Hip\u00f3tesis<\/strong><\/span><\/a><\/div>\n\n\n\n<div class=\"wp-block-stackable-button stk-block-button is-style-plain stk-block stk-e742afa\" data-block-id=\"e742afa\"><style>.stk-e742afa .stk-button{background:transparent !important;}.stk-e742afa .stk-button:hover:after{background:transparent !important;opacity:1 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-e742afa .stk-button:after{background:transparent !important;opacity:1 !important;}.stk-e742afa .stk-button__inner-text{color:#787e83 !important;}.stk-e742afa .stk-button:hover .stk-button__inner-text{color:var(--theme-palette-color-1, #0054a6) !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"#objetivos-especificos\"><span class=\"has-text-color stk-button__inner-text\"><strong>Objetivos<\/strong><\/span><\/a><\/div>\n\n\n\n<div class=\"wp-block-stackable-button stk-block-button is-style-plain stk-block stk-fbee63b\" data-block-id=\"fbee63b\"><style>.stk-fbee63b .stk-button{background:transparent !important;}.stk-fbee63b .stk-button:hover:after{background:transparent !important;opacity:1 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-fbee63b .stk-button:after{background:transparent !important;opacity:1 !important;}.stk-fbee63b .stk-button__inner-text{color:#787e83 !important;font-style:oblique !important;}.stk-fbee63b .stk-button:hover .stk-button__inner-text{color:var(--theme-palette-color-1, #0054a6) !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"#referencias-bibliograficas\"><span class=\"has-text-color stk-button__inner-text\"><strong>Referencias<\/strong><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-91feeab\" data-block-id=\"91feeab\"><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-7edb0bf\" data-block-id=\"7edb0bf\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-7edb0bf-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-bf23ad8\" data-v=\"4\" data-block-id=\"bf23ad8\"><style>.stk-bf23ad8-container{border-top-left-radius:var(--stk--preset--border-radius--large, 16px) !important;border-top-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--large, 16px) !important;overflow:hidden !important;box-shadow:0 0 0 2px #7878781a !important;border-top-width:1px !important;border-right-width:1px !important;border-bottom-width:1px !important;border-left-width:1px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-bf23ad8-container stk-hover-parent\"><div class=\"stk-block-content stk-inner-blocks stk-bf23ad8-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-41bcc1f\" id=\"1-justificacion-cientifica-por-que-este-proyecto\" data-block-id=\"41bcc1f\"><style>.stk-41bcc1f .stk-block-heading__bottom-line{height:0.5px !important;width:100% !important;background-color:var(--theme-palette-color-5, #E7EBEE) !important;}.stk-41bcc1f .stk-block-heading__text{font-size:30px !important;color:#003366 !important;}@media screen and (max-width:999px){.stk-41bcc1f .stk-block-heading__text{font-size:30px !important;}}<\/style><h2 class=\"stk-block-heading__text has-text-color\">1. Justificaci\u00f3n Cient\u00edfica: \u00bfPor qu\u00e9 este proyecto?<\/h2><div class=\"stk-block-heading__bottom-line\"><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-3be437c\" data-block-id=\"3be437c\"><style>.stk-3be437c .stk-block-text__text{font-size:16px !important;}@media screen and (max-width:999px){.stk-3be437c .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text\">La diabetes tipo 2 (DM2) es una enfermedad muy heterog\u00e9nea cuya edad de diagn\u00f3stico est\u00e1 disminuyendo dr\u00e1sticamente (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Alberti et al., 2004; Clark, 1998; EpData, 2021<\/a>). En la actualidad, aunque tradicionalmente era propia de adultos mayores (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Khan et al., 2020<\/a>), la DM2 de inicio temprano (en menores de 45 a\u00f1os) se ha convertido en un problema sanitario emergente a nivel mundial sobre el que a\u00fan existe poco conocimiento (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Sun et al., 2022<\/a>).<br><br>Esta presentaci\u00f3n precoz es preocupante porque se asocia con un mayor riesgo de complicaciones cr\u00f3nicas (<a href=\"#referencias\">TODAY Study Group 2021<\/a>) y una mortalidad que triplica la de la poblaci\u00f3n general, superando incluso a la de la diabetes tipo 1 aun con menor tiempo de evoluci\u00f3n (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Waerbaum et al 2006; Constantino et al 2013<\/a>), incluso en pacientes sin obesidad (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Zheng et al 2020<\/a>).<br><br>A nivel asistencial y terap\u00e9utico, esta poblaci\u00f3n joven presenta desaf\u00edos \u00fanicos. Por un lado, la enfermedad progresa m\u00e1s r\u00e1pido y responde peor a tratamientos habituales, como la metformina en monoterapia, lo que exige una mayor necesidad de intervenci\u00f3n farmacol\u00f3gica (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Pyle et al 2021<\/a>), dependiendo enormemente de la funci\u00f3n residual de las c\u00e9lulas beta a corto (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Zeitler et al 2015<\/a>) y largo plazo (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Zeitler et al 2022<\/a>). Por otro lado, su seguimiento m\u00e9dico es complejo al coincidir con la etapa laboral activa e implica retos a\u00f1adidos como el diagn\u00f3stico diferencial adecuado y la atenci\u00f3n a mujeres con posibilidad gestacional (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Misra et al 2022<\/a>), factores que influyen en el distr\u00e9s relacionado con la enfermedad (Bo et al 2020).<br><br>Cabe destacar que existen muy pocos ensayos cl\u00ednicos espec\u00edficos en esta poblaci\u00f3n (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Currie et al 2021, Laffel et al 2023<\/a>), aunque opciones como la cirug\u00eda bari\u00e1trica sugieren una mayor eficacia en estos pacientes j\u00f3venes (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Aung et al 2016<\/a>).<br><br>Adem\u00e1s, existen importantes vac\u00edos de conocimiento en los factores de riesgo. Se sabe que a mayor \u00edndice de masa corporal (IMC) menor es la edad de inicio (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Hillier &amp; Pedula, 2001; Twig et al., 2020<\/a>), pero faltan estudios que analicen c\u00f3mo los cambios de peso sostenidos a lo largo de la vida impactan en el desarrollo de complicaciones cardiovasculares (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">May\u00e9n et al., 2022; Dennis et al., 2019; Luo et al., 2020; Tirosh et al., 2011<\/a>). Desde el punto de vista gen\u00e9tico, tambi\u00e9n se carece de marcadores que permitan guiar decisiones terap\u00e9uticas personalizadas.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-805c7c9\" data-block-id=\"805c7c9\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-805c7c9-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-86c4b83\" data-v=\"4\" data-block-id=\"86c4b83\"><style>.stk-86c4b83 {border-top-left-radius:var(--stk--preset--border-radius--large, 16px) !important;border-top-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--large, 16px) !important;overflow:hidden !important;border-style:solid !important;border-color:var(--theme-palette-color-1, #0054a6) !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:0px !important;border-left-width:5px !important;}.stk-86c4b83-container{background-color:#e6f0fa !important;}.stk-86c4b83-container:before{background-color:#e6f0fa !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-86c4b83-container stk-hover-parent\"><div class=\"stk-block-content stk-inner-blocks stk-86c4b83-inner-blocks\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-28afb9a\" data-block-id=\"28afb9a\"><style>.stk-28afb9a .stk-block-text__text{font-size:16px !important;color:var(--theme-palette-color-1, #0054a6) !important;}@media screen and (max-width:999px){.stk-28afb9a .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text has-text-color\"><strong>Dado que hasta la fecha no existe en Espa\u00f1a ning\u00fan estudio enfocado en pacientes menores de 45 a\u00f1os con DM2, nace el proyecto D2Top. Alineado con la estrategia nacional IMPACT-T2D, este estudio crear\u00e1 una cohorte pron\u00f3stica poblacional exhaustiva para analizar las caracter\u00edsticas cl\u00ednicas, epidemiol\u00f3gicas y gen\u00e9ticas de la enfermedad. Esto permitir\u00e1 validar herramientas de inteligencia artificial y scores de riesgo polig\u00e9nico, con el fin \u00faltimo de mejorar la asistencia, el tratamiento y el pron\u00f3stico de las personas con DM2 de inicio temprano.<\/strong><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-c51ecf7\" id=\"2-hipotesis-de-partida-y-objetivos\" data-block-id=\"c51ecf7\"><style>.stk-c51ecf7 .stk-block-heading__bottom-line{height:0.5px !important;width:100% !important;background-color:var(--theme-palette-color-5, #E7EBEE) !important;}.stk-c51ecf7 .stk-block-heading__text{font-size:30px !important;color:#003366 !important;}@media screen and (max-width:999px){.stk-c51ecf7 .stk-block-heading__text{font-size:30px !important;}}<\/style><h2 class=\"stk-block-heading__text has-text-color\">2. Hip\u00f3tesis de partida y Objetivos<\/h2><div class=\"stk-block-heading__bottom-line\"><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-8d768ba\" data-block-id=\"8d768ba\"><style>.stk-8d768ba .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-f8b65df\" data-block-id=\"f8b65df\"><style>.stk-f8b65df .stk--svg-wrapper .stk--inner-svg svg:last-child{height:20px !important;width:20px !important;}.stk-f8b65df .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-f8b65df .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#00a3e0 !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-f8b65df\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-f-8-b-65-df-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-f-8-b-65-df-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M297.2 248.9C311.6 228.3 320 203.2 320 176c0-70.7-57.3-128-128-128S64 105.3 64 176c0 27.2 8.4 52.3 22.8 72.9c3.7 5.3 8.1 11.3 12.8 17.7l0 0c12.9 17.7 28.3 38.9 39.8 59.8c10.4 19 15.7 38.8 18.3 57.5H109c-2.2-12-5.9-23.7-11.8-34.5c-9.9-18-22.2-34.9-34.5-51.8l0 0 0 0c-5.2-7.1-10.4-14.2-15.4-21.4C27.6 247.9 16 213.3 16 176C16 78.8 94.8 0 192 0s176 78.8 176 176c0 37.3-11.6 71.9-31.4 100.3c-5 7.2-10.2 14.3-15.4 21.4l0 0 0 0c-12.3 16.8-24.6 33.7-34.5 51.8c-5.9 10.8-9.6 22.5-11.8 34.5H226.4c2.6-18.7 7.9-38.6 18.3-57.5c11.5-20.9 26.9-42.1 39.8-59.8l0 0 0 0 0 0c4.7-6.4 9-12.4 12.7-17.7zM192 128c-26.5 0-48 21.5-48 48c0 8.8-7.2 16-16 16s-16-7.2-16-16c0-44.2 35.8-80 80-80c8.8 0 16 7.2 16 16s-7.2 16-16 16zm0 384c-44.2 0-80-35.8-80-80V416H272v16c0 44.2-35.8 80-80 80z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-3bd6d5a\" id=\"hipotesis\" data-block-id=\"3bd6d5a\"><style>.stk-3bd6d5a .stk-block-heading__text{font-size:20px !important;}@media screen and (max-width:999px){.stk-3bd6d5a .stk-block-heading__text{font-size:20px !important;}}<\/style><h2 class=\"stk-block-heading__text\">Hip\u00f3tesis<\/h2><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-0c6e742\" data-block-id=\"0c6e742\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-0c6e742-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4e112bf\" data-v=\"4\" data-block-id=\"4e112bf\"><style>.stk-4e112bf-container{background-color:var(--theme-palette-color-6, #F3F5F9) !important;border-top-left-radius:var(--stk--preset--border-radius--large, 16px) !important;border-top-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--large, 16px) !important;overflow:hidden !important;box-shadow:0 0 0 1px #7878781a !important;}.stk-4e112bf-container:before{background-color:var(--theme-palette-color-6, #F3F5F9) !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4e112bf-container stk-hover-parent\"><div class=\"stk-block-content stk-inner-blocks stk-4e112bf-inner-blocks\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-68169c0\" data-block-id=\"68169c0\"><style>.stk-68169c0 .stk-block-text__text{font-size:16px !important;}@media screen and (max-width:999px){.stk-68169c0 .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text\">La DM2 de inicio temprano es un problema emergente y son necesarios m\u00e1s estudios (<a href=\"#referencias\" data-type=\"internal\" data-id=\"#referencias\">Sun et al., 2022<\/a>). Nuestra hip\u00f3tesis es que la DM2 de inicio temprano tiene implicaciones pronosticas adversas que desconocemos y de gran relevancia para la pr\u00e1ctica cl\u00ednica. El mayor conocimiento de la poblaci\u00f3n que la sufre nos puede permitir dise\u00f1ar intervenciones m\u00e1s eficientes, con impacto sobre el control gluc\u00e9mico, los factores de riesgo cardiovascular y las complicaciones de la DM2.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-6e68654\" data-block-id=\"6e68654\"><style>.stk-6e68654 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-70a20ad\" data-block-id=\"70a20ad\"><style>.stk-70a20ad .stk--svg-wrapper .stk--inner-svg svg:last-child{height:20px !important;width:20px !important;}.stk-70a20ad .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-70a20ad .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#00a3e0 !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-70a20ad\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-70-a-20-ad-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-70-a-20-ad-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M448 256A192 192 0 1 0 64 256a192 192 0 1 0 384 0zM0 256a256 256 0 1 1 512 0A256 256 0 1 1 0 256zm256 80a80 80 0 1 0 0-160 80 80 0 1 0 0 160zm0-224a144 144 0 1 1 0 288 144 144 0 1 1 0-288zM224 256a32 32 0 1 1 64 0 32 32 0 1 1 -64 0z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-59b8696\" id=\"objetivo-general\" data-block-id=\"59b8696\"><style>.stk-59b8696 .stk-block-heading__text{font-size:20px !important;}@media screen and (max-width:999px){.stk-59b8696 .stk-block-heading__text{font-size:20px !important;}}<\/style><h2 class=\"stk-block-heading__text\">Objetivo General<\/h2><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-aff5723\" data-block-id=\"aff5723\"><style>.stk-aff5723 {border-style:solid !important;border-color:#00a3e0 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:0px !important;border-left-width:2px !important;padding-left:var(--stk--preset--spacing--30, 0.67rem) !important;}.stk-aff5723 .stk-block-text__text{font-size:16px !important;}@media screen and (max-width:999px){.stk-aff5723 .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text\">Evaluar las caracter\u00edsticas cl\u00ednicas, epidemiol\u00f3gicas y gen\u00e9ticas de las personas con DM2 de inicio temprano en Gran Canaria, con especial atenci\u00f3n al efecto de la obesidad.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-5c0378a\" id=\"objetivos-especificos\" data-block-id=\"5c0378a\"><style>.stk-5c0378a .stk-block-heading__text{font-size:20px !important;}@media screen and (max-width:999px){.stk-5c0378a .stk-block-heading__text{font-size:20px !important;}}<\/style><h2 class=\"stk-block-heading__text\">Objetivos Espec\u00edficos<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-e08b614\" data-block-id=\"e08b614\"><style>.stk-e08b614 {margin-bottom:30px !important;}.stk-e08b614-column{--stk-column-gap:30px !important;row-gap:30px !important;}@media screen and (max-width:689px){.stk-e08b614 {max-width:410px !important;min-width:auto !important;margin-right:auto !important;margin-left:auto !important;}}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-e08b614-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-fc9c699\" data-v=\"4\" data-block-id=\"fc9c699\"><style>.stk-fc9c699-container{margin-top:0px !important;margin-right:0px !important;margin-bottom:0px !important;margin-left:0px !important;background-color:#e6f0fa !important;border-top-left-radius:8px !important;border-top-right-radius:8px !important;border-bottom-right-radius:8px !important;border-bottom-left-radius:8px !important;overflow:hidden !important;box-shadow:none !important;border-style:solid !important;border-color:var(--theme-palette-color-5, #E7EBEE) !important;padding-top:55px !important;padding-right:45px !important;padding-bottom:50px !important;padding-left:45px !important;}.stk-fc9c699-container:hover{background-color:var(--theme-palette-color-8, #ffffff) !important;box-shadow:0px 0px 19px 0px #0054a6 !important;border-color:#0054a6 !important;}.stk-fc9c699-container:before{background-color:#e6f0fa !important;}.stk-fc9c699-container:hover:before{background-color:var(--theme-palette-color-8, #ffffff) !important;}@media screen and (min-width:690px) and (max-width:999px){.stk-fc9c699 {flex:var(--stk-flex-grow, 1) 1 calc(33.333333333333336% - var(--stk-column-gap, 0px) * 2 \/ 3 ) !important;}}@media screen and (max-width:999px){.stk-fc9c699-container{padding-top:40px !important;padding-right:35px !important;padding-bottom:40px !important;padding-left:35px !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-fc9c699-container stk-hover-parent\"><div class=\"has-text-align-center-mobile stk-block-content stk-inner-blocks stk-fc9c699-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-center stk-block stk-0dc6b0e\" data-block-id=\"0dc6b0e\"><style>.stk-0dc6b0e .stk--svg-wrapper .stk--inner-svg svg:last-child{height:30px !important;width:30px !important;}.stk-0dc6b0e .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-0dc6b0e .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#bbc0d0 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-0dc6b0e .stk--svg-wrapper .stk--inner-svg svg:last-child,  :where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-0dc6b0e .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#0054a6 !important;}@media screen and (max-width:999px){.stk-0dc6b0e .stk--svg-wrapper .stk--inner-svg svg:last-child{height:25px !important;width:25px !important;}}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-0dc6b0e\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-0-dc-6-b-0-e-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-0-dc-6-b-0-e-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M228.3 469.1L47.6 300.4c-4.2-3.9-8.2-8.1-11.9-12.4h87c22.6 0 43-13.6 51.7-34.5l10.5-25.2 49.3 109.5c3.8 8.5 12.1 14 21.4 14.1s17.8-5 22-13.3L320 253.7l1.7 3.4c9.5 19 28.9 31 50.1 31H476.3c-3.7 4.3-7.7 8.5-11.9 12.4L283.7 469.1c-7.5 7-17.4 10.9-27.7 10.9s-20.2-3.9-27.7-10.9zM503.7 240h-132c-3 0-5.8-1.7-7.2-4.4l-23.2-46.3c-4.1-8.1-12.4-13.3-21.5-13.3s-17.4 5.1-21.5 13.3l-41.4 82.8L205.9 158.2c-3.9-8.7-12.7-14.3-22.2-14.1s-18.1 5.9-21.8 14.8l-31.8 76.3c-1.2 3-4.2 4.9-7.4 4.9H16c-2.6 0-5 .4-7.3 1.1C3 225.2 0 208.2 0 190.9v-5.8c0-69.9 50.5-129.5 119.4-141C165 36.5 211.4 51.4 244 84l12 12 12-12c32.6-32.6 79-47.5 124.6-39.9C461.5 55.6 512 115.2 512 185.1v5.8c0 16.9-2.8 33.5-8.3 49.1z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-2967449\" id=\"span-style-color-0054-a-6-class-stk-highlight-ob-1-span\" data-block-id=\"2967449\"><style>.stk-2967449 {margin-bottom:5px !important;}.stk-2967449 .stk-block-heading__text{font-size:20px !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-2967449 .stk-block-heading__text{color:var(--theme-palette-color-6, #F3F5F7) !important;}@media screen and (max-width:999px){.stk-2967449 .stk-block-heading__text{font-size:20px !important;}}<\/style><h3 class=\"stk-block-heading__text has-text-align-center\"><span style=\"color: #0054a6;\" class=\"stk-highlight\">OB1.<\/span><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-d560ff0\" data-block-id=\"d560ff0\"><style>.stk-d560ff0 .stk-block-text__text{font-size:16px !important;color:var(--theme-palette-color-3, #4d5d6d) !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-d560ff0 .stk-block-text__text{color:var(--theme-palette-color-4, #102136) !important;}@media screen and (max-width:999px){.stk-d560ff0 .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text has-text-color has-text-align-center\">Descripci\u00f3n cl\u00ednico-biol\u00f3gica-epidemiol\u00f3gica identificando factores asociados con la aparici\u00f3n m\u00e1s temprana de la DM2 y evaluando diferencias seg\u00fan la obesidad.<\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-c449828\" data-v=\"4\" data-block-id=\"c449828\"><style>.stk-c449828-container{margin-top:0px !important;margin-right:0px !important;margin-bottom:0px !important;margin-left:0px !important;background-color:#e6f0fa !important;border-top-left-radius:8px !important;border-top-right-radius:8px !important;border-bottom-right-radius:8px !important;border-bottom-left-radius:8px !important;overflow:hidden !important;box-shadow:0px 0px 0px 0px #0054a6 !important;border-style:solid !important;border-color:var(--theme-palette-color-5, #E7EBEE) !important;padding-top:55px !important;padding-right:45px !important;padding-bottom:50px !important;padding-left:45px !important;}.stk-c449828-container:hover{background-color:var(--theme-palette-color-8, #ffffff) !important;box-shadow:0px 0px 30px 0px #0054a6 !important;border-color:#0054a6 !important;}.stk-c449828-container:before{background-color:#e6f0fa !important;}.stk-c449828-container:hover:before{background-color:var(--theme-palette-color-8, #ffffff) !important;}@media screen and (min-width:690px) and (max-width:999px){.stk-c449828 {flex:var(--stk-flex-grow, 1) 1 calc(33.333333333333336% - var(--stk-column-gap, 0px) * 2 \/ 3 ) !important;}}@media screen and (max-width:999px){.stk-c449828-container{padding-top:40px !important;padding-right:35px !important;padding-bottom:40px !important;padding-left:35px !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-c449828-container stk-hover-parent\"><div class=\"has-text-align-center-mobile stk-block-content stk-inner-blocks stk-c449828-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-center stk-block stk-b7359ab\" data-block-id=\"b7359ab\"><style>.stk-b7359ab {margin-bottom:25px !important;}.stk-b7359ab .stk--svg-wrapper .stk--inner-svg svg:last-child{height:30px !important;width:30px !important;}.stk-b7359ab .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-b7359ab .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#bbc0d0 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-b7359ab .stk--svg-wrapper .stk--inner-svg svg:last-child,  :where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-b7359ab .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#0054a6 !important;}@media screen and (max-width:999px){.stk-b7359ab .stk--svg-wrapper .stk--inner-svg svg:last-child{height:25px !important;width:25px !important;}}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-b7359ab\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-b-7359-ab-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-b-7359-ab-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M416 0c17.7 0 32 14.3 32 32c0 59.8-30.3 107.5-69.4 146.6c-28 28-62.5 53.5-97.3 77.4l-2.5 1.7c-11.9 8.1-23.8 16.1-35.5 23.9l0 0 0 0 0 0-1.6 1c-6 4-11.9 7.9-17.8 11.9c-20.9 14-40.8 27.7-59.3 41.5H283.3c-9.8-7.4-20.1-14.7-30.7-22.1l7-4.7 3-2c15.1-10.1 30.9-20.6 46.7-31.6c25 18.1 48.9 37.3 69.4 57.7C417.7 372.5 448 420.2 448 480c0 17.7-14.3 32-32 32s-32-14.3-32-32H64c0 17.7-14.3 32-32 32s-32-14.3-32-32c0-59.8 30.3-107.5 69.4-146.6c28-28 62.5-53.5 97.3-77.4c-34.8-23.9-69.3-49.3-97.3-77.4C30.3 139.5 0 91.8 0 32C0 14.3 14.3 0 32 0S64 14.3 64 32H384c0-17.7 14.3-32 32-32zM338.6 384H109.4c-10.1 10.6-18.6 21.3-25.5 32H364.1c-6.8-10.7-15.3-21.4-25.5-32zM109.4 128H338.6c10.1-10.7 18.6-21.3 25.5-32H83.9c6.8 10.7 15.3 21.3 25.5 32zm55.4 48c18.4 13.8 38.4 27.5 59.3 41.5c20.9-14 40.8-27.7 59.3-41.5H164.7z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f7effd5\" id=\"span-style-color-0054-a-6-class-stk-highlight-ob-2-span\" data-block-id=\"f7effd5\"><style>.stk-f7effd5 {margin-bottom:5px !important;}.stk-f7effd5 .stk-block-heading__text{font-size:20px !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-f7effd5 .stk-block-heading__text{color:var(--theme-palette-color-6, #F3F5F7) !important;}@media screen and (max-width:999px){.stk-f7effd5 .stk-block-heading__text{font-size:20px !important;}}<\/style><h3 class=\"stk-block-heading__text has-text-align-center\"><span style=\"color: #0054a6;\" class=\"stk-highlight\">OB2.<\/span><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-f8ab3aa\" data-block-id=\"f8ab3aa\"><style>.stk-f8ab3aa .stk-block-text__text{font-size:16px !important;color:var(--theme-palette-color-3, #4d5d6d) !important;}.stk-f8ab3aa .stk-block-text__text:hover{color:var(--theme-palette-color-4, #102136) !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-f8ab3aa .stk-block-text__text{color:var(--theme-palette-color-4, #102136) !important;}@media screen and (max-width:999px){.stk-f8ab3aa .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text has-text-color has-text-align-center\">Evaluar el impacto de los cambios y trayectorias de grasa&nbsp;corporal&nbsp;en la DM2 de inicio temprano.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-774e5ec\" data-block-id=\"774e5ec\"><style>.stk-774e5ec {margin-bottom:30px !important;}.stk-774e5ec-column{--stk-column-gap:30px !important;row-gap:30px !important;}@media screen and (max-width:689px){.stk-774e5ec {max-width:410px !important;min-width:auto !important;margin-right:auto !important;margin-left:auto !important;}}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-774e5ec-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8b980ab\" data-v=\"4\" data-block-id=\"8b980ab\"><style>.stk-8b980ab-container{margin-top:0px !important;margin-right:0px !important;margin-bottom:0px !important;margin-left:0px !important;background-color:#e6f0fa !important;border-top-left-radius:8px !important;border-top-right-radius:8px !important;border-bottom-right-radius:8px !important;border-bottom-left-radius:8px !important;overflow:hidden !important;box-shadow:none !important;border-style:solid !important;border-color:var(--theme-palette-color-5, #E7EBEE) !important;padding-top:55px !important;padding-right:45px !important;padding-bottom:50px !important;padding-left:45px !important;}.stk-8b980ab-container:hover{background-color:var(--theme-palette-color-8, #ffffff) !important;box-shadow:0px 0px 26px 0px #0054a6 !important;border-color:#0054a6 !important;}.stk-8b980ab-container:before{background-color:#e6f0fa !important;}.stk-8b980ab-container:hover:before{background-color:var(--theme-palette-color-8, #ffffff) !important;}@media screen and (max-width:999px){.stk-8b980ab-container{padding-top:40px !important;padding-right:35px !important;padding-bottom:40px !important;padding-left:35px !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8b980ab-container stk-hover-parent\"><div class=\"has-text-align-center-mobile stk-block-content stk-inner-blocks stk-8b980ab-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-center stk-block stk-fc1ce8b\" data-block-id=\"fc1ce8b\"><style>.stk-fc1ce8b {margin-bottom:25px !important;}.stk-fc1ce8b .stk--svg-wrapper .stk--inner-svg svg:last-child{height:30px !important;width:30px !important;}.stk-fc1ce8b .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-fc1ce8b .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#bbc0d0 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-fc1ce8b .stk--svg-wrapper .stk--inner-svg svg:last-child,  :where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-fc1ce8b .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#0054a6 !important;}@media screen and (max-width:999px){.stk-fc1ce8b .stk--svg-wrapper .stk--inner-svg svg:last-child{height:25px !important;width:25px !important;}}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-fc1ce8b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-fc-1-ce-8-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-fc-1-ce-8-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M416 0c17.7 0 32 14.3 32 32c0 59.8-30.3 107.5-69.4 146.6c-28 28-62.5 53.5-97.3 77.4l-2.5 1.7c-11.9 8.1-23.8 16.1-35.5 23.9l0 0 0 0 0 0-1.6 1c-6 4-11.9 7.9-17.8 11.9c-20.9 14-40.8 27.7-59.3 41.5H283.3c-9.8-7.4-20.1-14.7-30.7-22.1l7-4.7 3-2c15.1-10.1 30.9-20.6 46.7-31.6c25 18.1 48.9 37.3 69.4 57.7C417.7 372.5 448 420.2 448 480c0 17.7-14.3 32-32 32s-32-14.3-32-32H64c0 17.7-14.3 32-32 32s-32-14.3-32-32c0-59.8 30.3-107.5 69.4-146.6c28-28 62.5-53.5 97.3-77.4c-34.8-23.9-69.3-49.3-97.3-77.4C30.3 139.5 0 91.8 0 32C0 14.3 14.3 0 32 0S64 14.3 64 32H384c0-17.7 14.3-32 32-32zM338.6 384H109.4c-10.1 10.6-18.6 21.3-25.5 32H364.1c-6.8-10.7-15.3-21.4-25.5-32zM109.4 128H338.6c10.1-10.7 18.6-21.3 25.5-32H83.9c6.8 10.7 15.3 21.3 25.5 32zm55.4 48c18.4 13.8 38.4 27.5 59.3 41.5c20.9-14 40.8-27.7 59.3-41.5H164.7z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-bc4881d\" id=\"span-style-color-0054-a-6-class-stk-highlight-ob-3-span\" data-block-id=\"bc4881d\"><style>.stk-bc4881d {margin-bottom:5px !important;}.stk-bc4881d .stk-block-heading__text{font-size:20px !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-bc4881d .stk-block-heading__text{color:var(--theme-palette-color-6, #F3F5F7) !important;}@media screen and (max-width:999px){.stk-bc4881d .stk-block-heading__text{font-size:20px !important;}}<\/style><h3 class=\"stk-block-heading__text has-text-align-center\"><span style=\"color: #0054a6;\" class=\"stk-highlight\">OB3.<\/span><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-907a490\" data-block-id=\"907a490\"><style>.stk-907a490 .stk-block-text__text{font-size:16px !important;color:var(--theme-palette-color-3, #4d5d6d) !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-907a490 .stk-block-text__text{color:var(--theme-palette-color-4, #102136) !important;}@media screen and (max-width:999px){.stk-907a490 .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text has-text-color has-text-align-center\">Validaci\u00f3n&nbsp;de las variantes gen\u00e9ticas raras y el&nbsp;<em>score de riesgo polig\u00e9nico<\/em>&nbsp;desarrollados en el consorcio IMPACT-T2D.<\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-e40cf50\" data-v=\"4\" data-block-id=\"e40cf50\"><style>.stk-e40cf50-container{margin-top:0px !important;margin-right:0px !important;margin-bottom:0px !important;margin-left:0px !important;background-color:#e6f0fa !important;border-top-left-radius:8px !important;border-top-right-radius:8px !important;border-bottom-right-radius:8px !important;border-bottom-left-radius:8px !important;overflow:hidden !important;box-shadow:none !important;border-style:solid !important;border-color:var(--theme-palette-color-5, #E7EBEE) !important;padding-top:55px !important;padding-right:45px !important;padding-bottom:50px !important;padding-left:45px !important;}.stk-e40cf50-container:hover{background-color:var(--theme-palette-color-8, #ffffff) !important;box-shadow:0px 0px 26px 0px #0054a6 !important;border-color:#0054a6 !important;}.stk-e40cf50-container:before{background-color:#e6f0fa !important;}.stk-e40cf50-container:hover:before{background-color:var(--theme-palette-color-8, #ffffff) !important;}@media screen and (max-width:999px){.stk-e40cf50-container{padding-top:40px !important;padding-right:35px !important;padding-bottom:40px !important;padding-left:35px !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-e40cf50-container stk-hover-parent\"><div class=\"has-text-align-center-mobile stk-block-content stk-inner-blocks stk-e40cf50-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-center stk-block stk-c7c4ae0\" data-block-id=\"c7c4ae0\"><style>.stk-c7c4ae0 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:30px !important;width:30px !important;}.stk-c7c4ae0 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-c7c4ae0 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#bbc0d0 !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-c7c4ae0 .stk--svg-wrapper .stk--inner-svg svg:last-child,  :where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-c7c4ae0 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#0054a6 !important;}@media screen and (max-width:999px){.stk-c7c4ae0 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:25px !important;width:25px !important;}}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-c7c4ae0\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-c-7-c-4-ae-0-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-c-7-c-4-ae-0-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M228.3 469.1L47.6 300.4c-4.2-3.9-8.2-8.1-11.9-12.4h87c22.6 0 43-13.6 51.7-34.5l10.5-25.2 49.3 109.5c3.8 8.5 12.1 14 21.4 14.1s17.8-5 22-13.3L320 253.7l1.7 3.4c9.5 19 28.9 31 50.1 31H476.3c-3.7 4.3-7.7 8.5-11.9 12.4L283.7 469.1c-7.5 7-17.4 10.9-27.7 10.9s-20.2-3.9-27.7-10.9zM503.7 240h-132c-3 0-5.8-1.7-7.2-4.4l-23.2-46.3c-4.1-8.1-12.4-13.3-21.5-13.3s-17.4 5.1-21.5 13.3l-41.4 82.8L205.9 158.2c-3.9-8.7-12.7-14.3-22.2-14.1s-18.1 5.9-21.8 14.8l-31.8 76.3c-1.2 3-4.2 4.9-7.4 4.9H16c-2.6 0-5 .4-7.3 1.1C3 225.2 0 208.2 0 190.9v-5.8c0-69.9 50.5-129.5 119.4-141C165 36.5 211.4 51.4 244 84l12 12 12-12c32.6-32.6 79-47.5 124.6-39.9C461.5 55.6 512 115.2 512 185.1v5.8c0 16.9-2.8 33.5-8.3 49.1z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-d289df7\" id=\"span-style-color-0054-a-6-class-stk-highlight-ob-4-span\" data-block-id=\"d289df7\"><style>.stk-d289df7 {margin-bottom:5px !important;}.stk-d289df7 .stk-block-heading__text{font-size:20px !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-d289df7 .stk-block-heading__text{color:var(--theme-palette-color-6, #F3F5F7) !important;}@media screen and (max-width:999px){.stk-d289df7 .stk-block-heading__text{font-size:20px !important;}}<\/style><h3 class=\"stk-block-heading__text has-text-align-center\"><span style=\"color: #0054a6;\" class=\"stk-highlight\">OB4.<\/span><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-25b1e73\" data-block-id=\"25b1e73\"><style>.stk-25b1e73 .stk-block-text__text{font-size:16px !important;color:var(--theme-palette-color-3, #4d5d6d) !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-25b1e73 .stk-block-text__text{color:var(--theme-palette-color-4, #102136) !important;}@media screen and (max-width:999px){.stk-25b1e73 .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text has-text-color has-text-align-center\">Generar la cohorte prospectiva D2Top de personas con DM2 de&nbsp;inicio&nbsp;temprano como un estudio bien caracterizado cl\u00ednica, epidemiol\u00f3gica y gen\u00e9ticamente para monitorizar su salud, alineado con estrategias nacionales para realizar futuros estudios pron\u00f3sticos y de medicina predictiva.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-5af37e8\" id=\"referencias-bibliograficas\" data-block-id=\"5af37e8\"><style>.stk-5af37e8 .stk-block-heading__bottom-line{height:0.5px !important;width:100% !important;background-color:var(--theme-palette-color-5, #E7EBEE) !important;}.stk-5af37e8 .stk-block-heading__text{font-size:30px !important;color:#003366 !important;}@media screen and (max-width:999px){.stk-5af37e8 .stk-block-heading__text{font-size:30px !important;}}<\/style><h2 class=\"stk-block-heading__text has-text-color\">Referencias Bibliogr\u00e1ficas<\/h2><div class=\"stk-block-heading__bottom-line\"><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-771b117 stk-block-background\" id=\"referencias\" data-block-id=\"771b117\"><style>.stk-771b117 {background-color:var(--theme-palette-color-6, #F3F5F9) !important;border-top-left-radius:var(--stk--preset--border-radius--large, 16px) !important;border-top-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--large, 16px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--large, 16px) !important;overflow:hidden !important;}.stk-771b117:before{background-color:var(--theme-palette-color-6, #F3F5F9) !important;}.stk-771b117 .stk-block-text__text{font-size:16px !important;}@media screen and (max-width:999px){.stk-771b117 .stk-block-text__text{font-size:16px !important;}}<\/style><p class=\"stk-block-text__text\"><strong>Alberti y Zimmet.<\/strong> Lancet Diabetes Endocrinol. 2014;2:e1-2. doi: 10.1016\/S2213-8587(13)70187-6.<br><strong>Aung et al.<\/strong> JAMA Surg. 2016;151:798-805. doi: 10.1001\/jamasurg.2016.1130.<br><strong>Bo et al.<\/strong> Primary Care Diabetes 2020;14:522-528. doi: 10.1016\/j.pcd.2020.02.003.<br><strong>Clark. <\/strong>Diabetes Care. 1998;21 Suppl 3:C32-4. doi: 10.2337\/diacare.21.3.c32.<br><strong>Constantino et al.<\/strong> Diabetes Care 2013;36:3863\u20133869. doi: 10.2337\/dc12-2455.<br><strong>Currie et al.<\/strong> Diabetes Ther 2021;12:2827-2856.<br><strong>Dennis et al.<\/strong> Lancet Diabetes Endocrinol. 2019;7:442-451. doi: 10.1016\/S2213-8587(19)30087-7.<br><strong>EpData, 2021. <\/strong>Encuesta Nacional de Salud. Portales estad\u00edsticos del Ministerio de Sanidad.<br><strong>Hillier y Pedula.<\/strong> Diabetes Care. 2001;24:1522-1527. doi: 10.2337\/diacare.24.9.1522.<br><strong>Khan et al.<\/strong> J Epidemiol Glob Health. 2020;10:107-111. doi: 10.2991\/jegh.k.191028.001.<br><strong>Luo et al.<\/strong> Nutr Metab Cardiovasc Dis. 2021;31:1063-1070. doi: 10.1016\/j.numecd.2020.12.019.<br><strong>May\u00e9n et al.<\/strong> Eur J Epidemiol 2022;37:915-929. doi: 10.1007\/s10654-022-00900-6.<br><strong>Misra et al. <\/strong>Diabetic Medicine. 2022;39:e14927. doi: 10.1111\/dme.14927.<br><strong>Pyle et al.<\/strong> Diabetologia 2021; doi: 10.100\/s00125-021-05480-w.<br><strong>Sun et al.<\/strong> Diabetes Res Clin Pract. 2022;183:109119. doi: 10.1016\/j.diabres.2021.109119.<br><strong>Tirosh et al.<\/strong> N Engl J Med. 2011;364:1315-1325. doi: 10.1056\/NEJMoa1006992.<br><strong>TODAY Study Group.<\/strong> N Engl J Med 2021; 385:416-426. doi: 10.1056\/NEJMoa2100165.<br><strong>Twig et al. <\/strong>Diabetes Care. 2020;43:1487-1495. doi: 10.2337\/dc19-1988.<br><strong>Waerbaum et al.<\/strong> Diabetologia 2016; doi: 10.1007\/s00125-005-0135-x.<br><strong>Zeitler et al.<\/strong> Diabetes Care 2015; doi: 10.2337\/dc15-0848.<br><strong>Zeitler et al.<\/strong> JCEM 2022; 107: e3384\u2013e3394. doi: 10.1210\/clinem\/dgac254.<br><strong>Zheng et al.<\/strong> Prev Chronic Dis (CDC) 2020;17:200076. doi: 10.5888\/pcd17.200076.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Proyecto D2 Top Justificaci\u00f3n Hip\u00f3tesis Objetivos Referencias 1. Justificaci\u00f3n Cient\u00edfica: \u00bfPor qu\u00e9 este proyecto? La diabetes tipo 2 (DM2) es una enfermedad muy heterog\u00e9nea cuya edad de diagn\u00f3stico est\u00e1 disminuyendo dr\u00e1sticamente (Alberti et al., 2004; Clark, 1998; EpData, 2021). En la actualidad, aunque tradicionalmente era propia de adultos mayores (Khan et al., 2020), la DM2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1190","page","type-page","status-publish","hentry"],"blocksy_meta":{"page_structure_type":"default","styles_descriptor":{"styles":{"desktop":"[data-prefix=\"single_page\"] {background-color:var(--theme-palette-color-5);background-image:none;}","tablet":"","mobile":""},"google_fonts":[],"version":6},"vertical_spacing_source":"custom","content_area_spacing":"bottom","background":{"background_type":"color","background_pattern":"type-1","background_image":{"attachment_id":null,"x":0,"y":0},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%)","background_repeat":"repeat","background_size":"auto","background_attachment":"scroll","patternColor":{"default":{"color":"#e5e7ea"}},"overlayColor":{"default":{"color":"CT_CSS_SKIP_RULE"}},"backgroundColor":{"default":{"color":"var(--theme-palette-color-5)"}}}},"_links":{"self":[{"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/pages\/1190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/comments?post=1190"}],"version-history":[{"count":38,"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/pages\/1190\/revisions"}],"predecessor-version":[{"id":1267,"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/pages\/1190\/revisions\/1267"}],"wp:attachment":[{"href":"https:\/\/d2top.ulpgc.es\/index.php\/wp-json\/wp\/v2\/media?parent=1190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}